The PKU-HKUST Shenzhen-Hong Kong Institution was established in August 1999 as a joint venture of the Shenzhen Municipal Government, Peking University (PKU) and the Hong Kong University of Science and Technology (HKUST). It is located in the Shenzhen Hi-tech Industrial Park. It strives to become a hi-tech base for incubation, venture capital, innovative technology management system, and training of hi-tech professionals in the Shenzhen-Hong Kong bay area. It is the most important collaborative base of PKU and HKUST outside their respective campuses.

Prof. LEE Joseph H W, Vice-President for Research and Graduate Studies of HKUST, also serves as Vice Director of the PKU-HKUST Shenzhen-Hong Kong Institution.